For modifications in the public domain: PUBLIC DOMAIN NOTICE This software is "United States Government Work" under the terms of the United States Copyright Act. It was written as part of the authors' official duties for the United States Government and thus cannot be copyrighted. This software is freely available to the public for use without a copyright notice. Restrictions cannot be placed on its present or future use. Although all reasonable efforts have been taken to ensure the accuracy and reliability of the software and associated data, the National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH) and the U.S. Government do not and cannot warrant the performance or results that may be obtained by using this software or data. NHGRI, NIH and the U.S. Government disclaim all warranties as to performance, merchantability or fitness for any particular purpose. Please cite the authors in any work or product based on this material.